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KMID : 0368820100490020235
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Journal of the Korean Neuropsychiatr Association
2010 Volume.49 No. 2 p.235 ~ p.240
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Abnormal Cerebral Benzodiazepine Receptors Binding Measured with [123I]-Iomazenil SPECT in Panic Disorder
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Rho Dae-Young
Park Kyung-Min
Kim Young-Kee
Lee Sang-Min
Ryu Young-Hoon
Kim Chan-Hyung
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Abstract
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Objectives: Researchers have long hypothesized that the benzodiazepine-GABA system plays a role in the pathophysiology of panic disorder (PD). However, previous neuroimaging studies have been inconclusive, possibly due to matching discrepancies between patients and controls, confounding medication factors, and/or image analyzing methods. This study aimed to compare benzodiazepine receptor binding between PD patients and healthy controls.
Methods: Via 123I-iomazenil single-photon emission computed tomography (IMZ-SPECT), we obtained regional brain patterns of benzodiazepine receptor binding for 12 unmedicated PD patients and 8 healthy age-and sex-matched volunteer controls. To analyze the image data, we used statistical parametric mapping (SPM).
Results: Benzodiazepine receptor binding showed a decrease in both the parietal and occipital lobes in PD patients as compared to controls. The anterior cingulate cortex, left parahippocampal gyrus, and both temporal lobes showed increased binding in PD patients.
Conclusion: Our findings provide evidence of an abnormal BZD-GABA system in PD patients, suggesting that basal and/or compensatory changes in inhibitory neurotransmissions contribute to the pathogenesis of human PD.
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KEYWORD
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Panic disorder, [123I]-Iomazenil SPECT, Benzodiazepine receptor
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